SYNTHESIS AND BIOLOGICAL ACTIVITIES OF PYRAZOLE DERIVATIVES AND METAL CHELATES WITH Ni (II), Cu (II), Cr (III), Co (III) and Zn (II) ions

Abstract

Pyrazole, a five-membered heterocycle containing two nitrogen atoms, is extensively found as a core framework in a huge library of heterocyclic compounds that envelops promising agro-chemical, fluorescent and biological potencies. Attributed to its several potential applications, there is a rise in the significance of designing novel pyrazoles, disclosing innovative routes for synthesizing pyrazoles, examining different potencies of pyrazoles, and seeking for potential applications of pyrazoles. This review consists of two parts. The first part provides an overview on the synthetic approaches to prepare pyrazoles derivatives and the synthesis of metal chelates using synthesized ligand and metal ions such as Ni (II), Cu (II), Cr (III), Co (III) and Zn (II).

The second part provides the overview of physical, analytical, spectral parameters and biological study of synthesized metal chelates from pyrazole derivative. Numerous pyrazoline derivatives have been found to possess considerable biological activities, which stimulated the research activity in this field. They have several prominent effects, such as antimicrobial, antimycobacterial, antifungal, antiamoebic, anti-inflammatory, analgesic, antidepressant and anticancer activities. The present review provides an insight view to pyrazolines synthesis and its biological activities along with the compilation of recent patents on pyrazolines.